Reformatting Rituximab into Human IgG2 and IgG4 Isotypes Dramatically Improves Apoptosis Induction In Vitro

The direct induction of cell death, or apoptosis, in target cells is one of the effector mechanisms for the anti CD20 antibody Rituximab. Here we provide evidence that Rituximab’s apoptotic ability is linked to the antibody IgG isotype. Reformatting Rituximab from the standard human IgG1 heavy chain...

Descripción completa

Detalles Bibliográficos
Autores principales: Könitzer, Jennifer D., Sieron, Annette, Wacker, Angelika, Enenkel, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694715/
https://www.ncbi.nlm.nih.gov/pubmed/26713448
http://dx.doi.org/10.1371/journal.pone.0145633

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694715/
https://www.ncbi.nlm.nih.gov/pubmed/26713448
http://dx.doi.org/10.1371/journal.pone.0145633

Ejemplares similares