Tankyrase inhibitors attenuate WNT/β-catenin signaling and inhibit growth of hepatocellular carcinoma cells

Deregulated WNT/β-catenin signaling contributes to the development of a subgroup of hepatocellular carcinoma (HCC), the second leading cause of cancer deaths worldwide. Within this pathway, the tankyrase enzymes (TNKS1 and TNKS2) degrade AXIN and thereby enhance β-catenin activity. We evaluate TNKS...

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Detalles Bibliográficos
Autores principales: Ma, Li, Wang, Xiaolin, Jia, Tao, Wei, Wei, Chua, Mei-Sze, So, Samuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694839/
https://www.ncbi.nlm.nih.gov/pubmed/26246473

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694839/
https://www.ncbi.nlm.nih.gov/pubmed/26246473

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