Cargando…

Disruption and inactivation of the PP2A complex promotes the proliferation and angiogenesis of hemangioma endothelial cells through activating AKT and ERK

Hemangioma is a benign vascular neoplasm of unknown etiology. In this study, we generated an endothelial-specific PyMT gene-expressing transgenic mouse model that spontaneously develops hemangioma. Based on this transgenic model, a specific binding between PyMT and the core AC dimer of protein phosp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xie, Furong, Bao, Xin, Yu, Jingshuang, Chen, Wantao, Wang, Lizhen, Zhang, Zhiyuan, Xu, Qin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694857/ https://www.ncbi.nlm.nih.gov/pubmed/26308070

Ejemplares similares

miR-300 inhibits epithelial to mesenchymal transition and metastasis by targeting Twist in human epithelial cancer
por: Yu, Jingshuang, et al.
Publicado: (2014)

The proliferation and angiogenesis in hemangioma-derived endothelial cells is affected by STC2 medicated VEGFR2/Akt/eNOS pathway
por: Ren, Shanshan, et al.
Publicado: (2023)

Concanavalin A promotes angiogenesis and proliferation in endothelial cells through the Akt/ERK/Cyclin D1 axis
por: Li, Jing-Zhou, et al.
Publicado: (2021)

Erk1 and Erk2 Regulate Endothelial Cell Proliferation and Migration during Mouse Embryonic Angiogenesis
por: Srinivasan, Ruchika, et al.
Publicado: (2009)

Anlotinib Suppresses Colorectal Cancer Proliferation and Angiogenesis via Inhibition of AKT/ERK Signaling Cascade
por: Yang, Qian, et al.
Publicado: (2020)

Itraconazole inhibits proliferation, induces apoptosis, and reduces angiogenesis of hemangioma endothelial cells by downregulating the hedgehog signaling pathway
por: Dong, Jianyong, et al.
Publicado: (2023)

Combinative effects of β-elemene and propranolol on the proliferation, migration, and angiogenesis of hemangioma
por: Wang, Zhenyu, et al.
Publicado: (2023)

MicroRNA‑203a‑3p suppresses endothelial cell proliferation and invasion, and promotes apoptosis in hemangioma by inactivating the VEGF‑mediated PI3K/AKT pathway
por: Hu, Zhenfeng, et al.
Publicado: (2022)

Soluble Flt-1 in AMI Patients Serum Inhibits Angiogenesis of Endothelial Progenitor Cells by Suppressing Akt and Erk’s Activity
por: Zhang, Lijie, et al.
Publicado: (2022)

Sildenafil suppresses the proliferation and enhances the apoptosis of hemangioma endothelial cells
por: He, Xiaopo, et al.
Publicado: (2017)

Brazilian Propolis Suppresses Angiogenesis by Inducing Apoptosis in Tube-Forming Endothelial Cells through Inactivation of Survival Signal ERK1/2
por: Kunimasa, Kazuhiro, et al.
Publicado: (2011)

Chemokine receptor 7 targets the vascular endothelial growth factor via the AKT/ERK pathway to regulate angiogenesis in colon cancer
por: Li, Xiang, et al.
Publicado: (2019)

An interesting case of angiogenesis in cavernous hemangioma
por: Das, Dipankar, et al.
Publicado: (2016)

Krukovine Suppresses KRAS-Mutated Lung Cancer Cell Growth and Proliferation by Inhibiting the RAF-ERK Pathway and Inactivating AKT Pathway
por: Lai, Huanling, et al.
Publicado: (2018)

KIAA0247 suppresses the proliferation, angiogenesis and promote apoptosis of human glioma through inactivation of the AKT and Stat3 signaling pathway
por: Tan, Ying, et al.
Publicado: (2016)

NR3C2 suppresses the proliferation, migration, invasion and angiogenesis of colon cancer cells by inhibiting the AKT/ERK signaling pathway
por: Li, Jia, et al.
Publicado: (2022)

The role of β-adrenergic receptor signaling in the proliferation of hemangioma-derived endothelial cells
por: Ji, Yi, et al.
Publicado: (2013)

Urea immunoliposome inhibits human vascular endothelial cell proliferation for hemangioma treatment
por: Wang, Zhiliang, et al.
Publicado: (2013)

Participation of Intussusceptive Angiogenesis in the Morphogenesis of Lobular Capillary Hemangioma
por: Díaz-Flores, Lucio, et al.
Publicado: (2020)

Dextran-Catechin inhibits angiogenesis by disrupting copper homeostasis in endothelial cells
por: Yee, Eugene M. H., et al.
Publicado: (2017)

Endothelial deletion of Wt1 disrupts coronary angiogenesis and myocardium development
por: Ramiro-Pareta, Marina, et al.
Publicado: (2023)

Knockdown of VEGFR2 Inhibits Proliferation and Induces Apoptosis in Hemangioma-Derived Endothelial Cells
por: Ou, J.M., et al.
Publicado: (2014)

PP242 suppresses cell proliferation, metastasis, and angiogenesis of gastric cancer through inhibition of the PI3K/AKT/mTOR pathway
por: Xing, Xiaofang, et al.
Publicado: (2014)

HDAC10 promotes angiogenesis in endothelial cells through the PTPN22/ERK axis
por: Duan, Baoyu, et al.
Publicado: (2017)

Blocking TBK1 alleviated radiation-induced pulmonary fibrosis and epithelial-mesenchymal transition through Akt-Erk inactivation
por: Qu, Hongjin, et al.
Publicado: (2019)

Lycium barbarum polysaccharide induced apoptosis and inhibited proliferation in infantile hemangioma endothelial cells via down-regulation of PI3K/AKT signaling pathway
por: Lou, Lin, et al.
Publicado: (2019)

Protein abundance of AKT and ERK pathway components governs cell type‐specific regulation of proliferation
por: Adlung, Lorenz, et al.
Publicado: (2017)

Knockdown of CCL28 inhibits endometriosis stromal cell proliferation and invasion via ERK signaling pathway inactivation
por: Wu, Yingting, et al.
Publicado: (2022)

Vaccarin hastens wound healing by promoting angiogenesis via activation of MAPK/ERK and PI3K/AKT signaling pathways in vivo
por: Hou, Bao, et al.
Publicado: (2020)

MiR-21 Induced Angiogenesis through AKT and ERK Activation and HIF-1α Expression
por: Liu, Ling-Zhi, et al.
Publicado: (2011)

COSMC Is Overexpressed in Proliferating Infantile Hemangioma and Enhances Endothelial Cell Growth via VEGFR2
por: Lee, Jian-Jr, et al.
Publicado: (2013)

Targeting Cadherin-17 Inactivates Ras/Raf/MEK/ERK Signaling and Inhibits Cell Proliferation in Gastric Cancer
por: Lin, Zhaohu, et al.
Publicado: (2014)

KIAA1429 promotes infantile hemangioma regression by facilitating the stemness of hemangioma endothelial cells
por: Wang, Luying, et al.
Publicado: (2023)

Reduced FRG1 expression promotes angiogenesis via activation of the FGF2‐mediated ERK/AKT pathway
por: Mukherjee, Bratati, et al.
Publicado: (2023)

ERas regulates cell proliferation and epithelial–mesenchymal transition by affecting Erk/Akt signaling pathway in pancreatic cancer
por: Liu, Yang, et al.
Publicado: (2020)

Low Concentration of Rapamycin Inhibits Hemangioma Endothelial Cell Proliferation, Migration, and Vascular Tumor Formation in Mice
por: Zheng, Ningning, et al.
Publicado: (2014)

Proliferating Infantile Hemangioma Tissues and Primary Cell Lines Express Markers Associated with Endothelial-to-Mesenchymal Transition
por: Itinteang, Tinte, et al.
Publicado: (2020)

Retraction: Rapamycin Inhibits Proliferation of Hemangioma Endothelial Cells by Reducing HIF-1-Dependent Expression of VEGF
Publicado: (2020)

Endothelial deletion of Ino80 disrupts coronary angiogenesis and causes congenital heart disease
por: Rhee, Siyeon, et al.
Publicado: (2018)

Ghrelin Stimulates Endothelial Cells Angiogenesis through Extracellular Regulated Protein Kinases (ERK) Signaling Pathway
por: Wang, Jun, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_dgu4qvk358oj47dpdiqjn6ffqf