Cargando…

Liver X Receptor ligand cytotoxicity in colon cancer cells and not in normal colon epithelial cells depends on LXRβ subcellular localization

Increasing evidence indicates that Liver X Receptors (LXRs) have some anticancer properties. We recently demonstrated that LXR ligands induce colon cancer cell pyroptosis through an LXRβ-dependent pathway. In the present study, we showed that human colon cancer cell lines presented differential cyto...

Descripción completa

Detalles Bibliográficos
Autores principales:	Courtaut, Flavie, Derangère, Valentin, Chevriaux, Angélique, Ladoire, Sylvain, Cotte, Alexia K., Arnould, Laurent, Boidot, Romain, Rialland, Mickaël, Ghiringhelli, François, Rébé, Cédric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2015
Materias:	Priority Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694942/ https://www.ncbi.nlm.nih.gov/pubmed/26450852

Ejemplares similares

Induction of pyroptosis in colon cancer cells by LXRβ
por: Rébé, Cédric, et al.
Publicado: (2015)

Does bevacizumab impact anti-EGFR therapy efficacy in metastatic colorectal cancer?
por: Derangère, Valentin, et al.
Publicado: (2016)

HSP70 is a negative regulator of NLRP3 inflammasome activation
por: Martine, Pierre, et al.
Publicado: (2019)

PIK3CA and PIK3R1 tumor mutational landscape in a pan-cancer patient cohort and its association with pathway activation and treatment efficacy
por: Tharin, Zoé, et al.
Publicado: (2023)

Cathepsin B Is Required for NLRP3 Inflammasome Activation in Macrophages, Through NLRP3 Interaction
por: Chevriaux, Angélique, et al.
Publicado: (2020)

RAS status and neoadjuvant chemotherapy impact CD8+ cells and tumor HLA class I expression in liver metastatic colorectal cancer
por: Ledys, Fanny, et al.
Publicado: (2018)

Identification of Biological Markers of Liver X Receptor (LXR) Activation at the Cell Surface of Human Monocytes
por: Rébé, Cédric, et al.
Publicado: (2012)

Fluorouracil and bevacizumab plus anakinra for patients with metastatic colorectal cancer refractory to standard therapies (IRAFU): a single-arm phase 2 study
por: Isambert, Nicolas, et al.
Publicado: (2018)

Evaluation of tumor immune contexture among intrinsic molecular subtypes helps to predict outcome in early breast cancer
por: Klopfenstein, Quentin, et al.
Publicado: (2021)

Bleomycin Exerts Ambivalent Antitumor Immune Effect by Triggering Both Immunogenic Cell Death and Proliferation of Regulatory T Cells
por: Bugaut, Hélène, et al.
Publicado: (2013)

Molecular intrinsic subtypes, genomic, and immune landscapes of BRCA-proficient but HRD-high ER-positive/HER2-negative early breast cancers
por: Ballot, Elise, et al.
Publicado: (2022)

Preliminary evaluation of deep learning for first-line diagnostic prediction of tumor mutational status
por: Morel, Louis-Oscar, et al.
Publicado: (2023)

Efficacy of platinum-based chemotherapy in metastatic breast cancer and HRD biomarkers: utility of exome sequencing
por: Galland, Loïck, et al.
Publicado: (2022)

Association of Anti-EGFR Antibody and MEK Inhibitor in Gynecological Cancer Harboring RAS Mutation: A Case Series
por: Niogret, Julie, et al.
Publicado: (2022)

Custom multi-tumor next-generation sequencing panel for routine molecular diagnosis of solid tumors: Validation and results from three-year clinical use
por: Chevrier, Sandy, et al.
Publicado: (2022)

IRF8-dependent molecular complexes control the Th9 transcriptional program
por: Humblin, Etienne, et al.
Publicado: (2017)

Phenolic extract from oleaster (Olea europaea var. Sylvestris) leaves reduces colon cancer growth and induces caspase-dependent apoptosis in colon cancer cells via the mitochondrial apoptotic pathway
por: Zeriouh, Wafa, et al.
Publicado: (2017)

Correction: Phenolic extract from oleaster (Olea europaea var. Sylvestris) leaves reduces colon cancer growth and induces caspase-dependent apoptosis in colon cancer cells via the mitochondrial apoptotic pathway
por: Zeriouh, Wafa, et al.
Publicado: (2017)

TCR Clonality and Genomic Instability Signatures as Prognostic Biomarkers in High Grade Serous Ovarian Cancer
por: Lecuelle, Julie, et al.
Publicado: (2021)

T-bet expression in intratumoral lymphoid structures after neoadjuvant trastuzumab plus docetaxel for HER2-overexpressing breast carcinoma predicts survival
por: Ladoire, S, et al.
Publicado: (2011)

The transfer of multigene panel testing for hereditary breast and ovarian cancer to healthcare: What are the implications for the management of patients and families?
por: Eliade, Marie, et al.
Publicado: (2016)

Downregulation of Elovl5 promotes breast cancer metastasis through a lipid-droplet accumulation-mediated induction of TGF-β receptors
por: Kieu, Trinh-Le-Vi, et al.
Publicado: (2022)

Metabolic reprogramming of the premalignant colonic mucosa is an early event in carcinogenesis
por: Cruz, Mart Dela, et al.
Publicado: (2017)

Clinical Utility of Genomic Tests Evaluating Homologous Recombination Repair Deficiency (HRD) for Treatment Decisions in Early and Metastatic Breast Cancer
por: Galland, Loïck, et al.
Publicado: (2023)

Induction of KIAA1199/CEMIP is associated with colon cancer phenotype and poor patient survival
por: Fink, Stephen P., et al.
Publicado: (2015)

Oncogenic KRAS activates an embryonic stem cell-like program in human colon cancer initiation
por: Le Rolle, Anne-France, et al.
Publicado: (2016)

Pharmacological inhibition of p38 MAPK reduces tumor growth in patient-derived xenografts from colon tumors
por: Gupta, Jalaj, et al.
Publicado: (2015)

Interleukin-4 and interleukin-13 increase NADPH oxidase 1-related proliferation of human colon cancer cells
por: Liu, Han, et al.
Publicado: (2017)

Interleukin-1β and Cancer
por: Rébé, Cédric, et al.
Publicado: (2020)

STAT3, a Master Regulator of Anti-Tumor Immune Response
por: Rébé, Cédric, et al.
Publicado: (2019)

Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models
por: Bianchi, Giovanna, et al.
Publicado: (2015)

Comparison of SARS-CoV-2 RT-PCR on a high-throughput molecular diagnostic platform and the cobas SARS-CoV-2 test for the diagnostic of COVID-19 on various clinical samples
por: Opota, Onya, et al.
Publicado: (2020)

Fra-1 is a key driver of colon cancer metastasis and a Fra-1 classifier predicts disease-free survival
por: Iskit, Sedef, et al.
Publicado: (2015)

Exome-Based Genomic Markers Could Improve Prediction of Checkpoint Inhibitor Efficacy Independently of Tumor Type
por: Dalens, Lorraine, et al.
Publicado: (2023)

Prognostic and predictive role of CD8 and PD-L1 determination in lung tumor tissue of patients under anti-PD-1 therapy
por: Fumet, Jean-David, et al.
Publicado: (2018)

Correction: Prognostic and predictive role of CD8 and PD-L1 determination in lung tumor tissue of patients under anti-PD-1 therapy
por: Fumet, Jean-David, et al.
Publicado: (2019)

ErbB-3 activation by NRG-1β sustains growth and promotes vemurafenib resistance in BRAF-V600E colon cancer stem cells (CSCs)
por: Prasetyanti, Pramudita R., et al.
Publicado: (2015)

Understanding Inflammasomes and PD-1/PD-L1 Crosstalk to Improve Cancer Treatment Efficiency
por: Perrichet, Anaïs, et al.
Publicado: (2020)

Editorial: Inflammasomes: Cornerstone of Immunity
por: Rébé, Cédric, et al.
Publicado: (2022)

Tumor Immunogenic Cell Death as a Mediator of Intratumor CD8 T-Cell Recruitment
por: Roussot, Nicolas, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_cehlvm1tcm7eku7cpb377966c0