Depletion of the cisplatin targeted HMGB-box factor UBF selectively induces p53-independent apoptotic death in transformed cells

Cisplatin-DNA adducts act as strong decoys for the Upstream Binding Factor UBF (UBTF) and have been shown to inhibit transcription of the ribosomal RNA genes by RNA polymerase I. However, it is unclear if this plays a significant role in the chemotherapeutic activity of cis- or carboplatin. We find...

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Detalles Bibliográficos
Autores principales: Hamdane, Nourdine, Herdman, Chelsea, Mars, Jean-Clement, Stefanovsky, Victor, Tremblay, Michel G., Moss, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695006/
https://www.ncbi.nlm.nih.gov/pubmed/26317157

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695006/
https://www.ncbi.nlm.nih.gov/pubmed/26317157

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