AZD1775 sensitizes T cell acute lymphoblastic leukemia cells to cytarabine by promoting apoptosis over DNA repair

While some children with acute lymphoblastic leukemia (ALL) have excellent prognoses, the prognosis for adults and children with T cell ALL is more guarded. Treatment for T-ALL is heavily dependent upon antimetabolite chemotherapeutics, including cytarabine. Targeted inhibition of WEE1 with AZD1775...

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Detalles Bibliográficos
Autores principales: Ford, James B., Baturin, Dmitry, Burleson, Tamara M., Van Linden, Annemie A., Kim, Yong-Mi, Porter, Christopher C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695040/
https://www.ncbi.nlm.nih.gov/pubmed/26334102

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695040/
https://www.ncbi.nlm.nih.gov/pubmed/26334102

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