Dual mTORC1/C2 inhibitors suppress cellular geroconversion (a senescence program)

In proliferating cells, mTOR is active and promotes cell growth. When the cell cycle is arrested, then mTOR converts reversible arrest to senescence (geroconversion). Rapamycin and other rapalogs suppress geroconversion, maintaining quiescence instead. Here we showed that ATP-competitive kinase inhi...

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Detalles Bibliográficos
Autores principales: Leontieva, Olga V., Demidenko, Zoya N., Blagosklonny, Mikhail V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper: Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695114/
https://www.ncbi.nlm.nih.gov/pubmed/26177051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695114/
https://www.ncbi.nlm.nih.gov/pubmed/26177051

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