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Cisplatin inhibits MEK1/2

Cisplatin (cDDP) is known to bind to the CXXC motif of proteins containing a ferrodoxin-like fold but little is known about its ability to interact with other Cu-binding proteins. MEK1/2 has recently been identified as a Cu-dependent enzyme that does not contain a CXXC motif. We found that cDDP boun...

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Detalles Bibliográficos
Autores principales: Yamamoto, Tetsu, Tsigelny, Igor F., Götz, Andreas W., Howell, Stephen B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695133/
https://www.ncbi.nlm.nih.gov/pubmed/26155939