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Cisplatin inhibits MEK1/2
Cisplatin (cDDP) is known to bind to the CXXC motif of proteins containing a ferrodoxin-like fold but little is known about its ability to interact with other Cu-binding proteins. MEK1/2 has recently been identified as a Cu-dependent enzyme that does not contain a CXXC motif. We found that cDDP boun...
Autores principales: | Yamamoto, Tetsu, Tsigelny, Igor F., Götz, Andreas W., Howell, Stephen B. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695133/ https://www.ncbi.nlm.nih.gov/pubmed/26155939 |
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