Cargando…

5mC-hydroxylase activity is influenced by the PARylation of TET1 enzyme

5-hydroxymethylcytosine is a new epigenetic modification deriving from the oxidation of 5-methylcytosine by the TET hydroxylase enzymes. DNA hydroxymethylation drives DNA demethylation events and is involved in the control of gene expression. Deregulation of TET enzymes causes developmental defects...

Descripción completa

Detalles Bibliográficos
Autores principales: Ciccarone, Fabio, Valentini, Elisabetta, Zampieri, Michele, Caiafa, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695189/
https://www.ncbi.nlm.nih.gov/pubmed/26136340