Regulation of mRNA Levels by Decay-Promoting Introns that Recruit the Exosome Specificity Factor Mmi1

In eukaryotic cells, inefficient splicing is surprisingly common and leads to the degradation of transcripts with retained introns. How pre-mRNAs are committed to nuclear decay is unknown. Here, we uncover a mechanism by which specific intron-containing transcripts are targeted for nuclear degradati...

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Detalles Bibliográficos
Autores principales: Kilchert, Cornelia, Wittmann, Sina, Passoni, Monica, Shah, Sneha, Granneman, Sander, Vasiljeva, Lidia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695336/
https://www.ncbi.nlm.nih.gov/pubmed/26670050
http://dx.doi.org/10.1016/j.celrep.2015.11.026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695336/
https://www.ncbi.nlm.nih.gov/pubmed/26670050
http://dx.doi.org/10.1016/j.celrep.2015.11.026

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