Nucleotide Pool Depletion Induces G-Quadruplex-Dependent Perturbation of Gene Expression

Nucleotide pool imbalance has been proposed to drive genetic instability in cancer. Here, we show that slowing replication forks by depleting nucleotide pools with hydroxyurea (HU) can also give rise to both transient and permanent epigenetic instability of a reporter locus, BU-1, in DT40 cells. HU...

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Detalles Bibliográficos
Autores principales: Papadopoulou, Charikleia, Guilbaud, Guillaume, Schiavone, Davide, Sale, Julian E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695339/
https://www.ncbi.nlm.nih.gov/pubmed/26686635
http://dx.doi.org/10.1016/j.celrep.2015.11.039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695339/
https://www.ncbi.nlm.nih.gov/pubmed/26686635
http://dx.doi.org/10.1016/j.celrep.2015.11.039

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