siRNA screen identifies QPCT as a druggable target for Huntington’s disease

Huntington’s disease (HD) is a currently incurable neurodegenerative condition caused by an abnormally expanded polyglutamine tract in huntingtin (HTT). We identified novel modifiers of mutant HTT toxicity by performing a large-scale “druggable genome” siRNA screen in human cultured cells, followed...

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Detalles Bibliográficos
Autores principales: Jimenez-Sanchez, Maria, Lam, Wun, Hannus, Michael, Sönnichsen, Birte, Imarisio, Sara, Fleming, Angeleen, Tarditi, Alessia, Menzies, Fiona, Dami, Teresa Ed, Xu, Catherine, Gonzalez-Couto, Eduardo, Lazzeroni, Giulia, Heitz, Freddy, Diamanti, Daniela, Massai, Luisa, Satagopam, Venkata P., Marconi, Guido, Caramelli, Chiara, Nencini, Arianna, Andreini, Matteo, Sardone, Gian Luca, Caradonna, Nicola P., Porcari, Valentina, Scali, Carla, Schneider, Reinhard, Pollio, Giuseppe, O’Kane, Cahir J., Caricasole, Andrea, Rubinsztein, David C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696152/
https://www.ncbi.nlm.nih.gov/pubmed/25848931
http://dx.doi.org/10.1038/nchembio.1790

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696152/
https://www.ncbi.nlm.nih.gov/pubmed/25848931
http://dx.doi.org/10.1038/nchembio.1790

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