Artificial neural network cascade identifies multi-P450 inhibitors in natural compounds

Substantial evidence has shown that most exogenous substances are metabolized by multiple cytochrome P450 (P450) enzymes instead of by merely one P450 isoform. Thus, multi-P450 inhibition leads to greater drug-drug interaction risk than specific P450 inhibition. Herein, we innovatively established a...

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Detalles Bibliográficos
Autores principales: Li, Zhangming, Li, Yan, Sun, Lu, Tang, Yun, Liu, Lanru, Zhu, Wenliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2015
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696407/
https://www.ncbi.nlm.nih.gov/pubmed/26719820
http://dx.doi.org/10.7717/peerj.1524

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696407/
https://www.ncbi.nlm.nih.gov/pubmed/26719820
http://dx.doi.org/10.7717/peerj.1524

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