TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production

Generation of β-amyloid (Aβ) peptide in Alzheimer's disease involves cleavage of amyloid precursor protein (APP) by γ-secretase, a protease known to cleave several substrates, including Notch. Finding specific modulators for γ-secretase could be a potential avenue to treat the disease. Here, we...

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Detalles Bibliográficos
Autores principales: Wang, Junfeng, Lu, Rui, Yang, Jian, Li, Hongyu, He, Zhuohao, Jing, Naihe, Wang, Xiaomin, Wang, Yizheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696454/
https://www.ncbi.nlm.nih.gov/pubmed/26581893
http://dx.doi.org/10.1038/ncomms9876

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696454/
https://www.ncbi.nlm.nih.gov/pubmed/26581893
http://dx.doi.org/10.1038/ncomms9876

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