Genomic Methylation Inhibits Expression of Hepatitis B Virus Envelope Protein in Transgenic Mice: A Non-Infectious Mouse Model to Study Silencing of HBV Surface Antigen Genes

OBJECTIVE: The Hepatitis B virus genome persists in the nucleus of virus infected hepatocytes where it serves as template for viral mRNA synthesis. Epigenetic modifications, including methylation of the CpG islands contribute to the regulation of viral gene expression. The present study investigates...

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Detalles Bibliográficos
Autores principales: Graumann, Franziska, Churin, Yuri, Tschuschner, Annette, Reifenberg, Kurt, Glebe, Dieter, Roderfeld, Martin, Roeb, Elke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696744/
https://www.ncbi.nlm.nih.gov/pubmed/26717563
http://dx.doi.org/10.1371/journal.pone.0146099

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696744/
https://www.ncbi.nlm.nih.gov/pubmed/26717563
http://dx.doi.org/10.1371/journal.pone.0146099

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