Engineering FKBP-Based Destabilizing Domains to Build Sophisticated Protein Regulation Systems

Targeting protein stability with small molecules has emerged as an effective tool to control protein abundance in a fast, scalable and reversible manner. The technique involves tagging a protein of interest (POI) with a destabilizing domain (DD) specifically controlled by a small molecule. The succe...

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Detalles Bibliográficos
Autores principales: An, Wenlin, Jackson, Rachel E., Hunter, Paul, Gögel, Stefanie, van Diepen, Michiel, Liu, Karen, Meyer, Martin P., Eickholt, Britta J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696822/
https://www.ncbi.nlm.nih.gov/pubmed/26717575
http://dx.doi.org/10.1371/journal.pone.0145783

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696822/
https://www.ncbi.nlm.nih.gov/pubmed/26717575
http://dx.doi.org/10.1371/journal.pone.0145783

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