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Engineering FKBP-Based Destabilizing Domains to Build Sophisticated Protein Regulation Systems
Targeting protein stability with small molecules has emerged as an effective tool to control protein abundance in a fast, scalable and reversible manner. The technique involves tagging a protein of interest (POI) with a destabilizing domain (DD) specifically controlled by a small molecule. The succe...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696822/ https://www.ncbi.nlm.nih.gov/pubmed/26717575 http://dx.doi.org/10.1371/journal.pone.0145783 |