Why do Sequence Signatures Predict Enzyme Mechanism? Homology versus Chemistry

First, we identify InterPro sequence signatures representing evolutionary relatedness and, second, signatures identifying specific chemical machinery. Thus, we predict the chemical mechanisms of enzyme-catalyzed reactions from catalytic and non-catalytic subsets of InterPro signatures. We first scan...

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Detalles Bibliográficos
Autores principales: Beattie, Kirsten E., De Ferrari, Luna, Mitchell, John B. O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696837/
https://www.ncbi.nlm.nih.gov/pubmed/26740739
http://dx.doi.org/10.4137/EBO.S31482

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696837/
https://www.ncbi.nlm.nih.gov/pubmed/26740739
http://dx.doi.org/10.4137/EBO.S31482

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