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Why do Sequence Signatures Predict Enzyme Mechanism? Homology versus Chemistry
First, we identify InterPro sequence signatures representing evolutionary relatedness and, second, signatures identifying specific chemical machinery. Thus, we predict the chemical mechanisms of enzyme-catalyzed reactions from catalytic and non-catalytic subsets of InterPro signatures. We first scan...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Libertas Academica
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696837/ https://www.ncbi.nlm.nih.gov/pubmed/26740739 http://dx.doi.org/10.4137/EBO.S31482 |