KPU-300, a Novel Benzophenone–Diketopiperazine–Type Anti-Microtubule Agent with a 2-Pyridyl Structure, Is a Potent Radiosensitizer That Synchronizes the Cell Cycle in Early M Phase

KPU-300 is a novel colchicine-type anti-microtubule agent derived from plinabulin (NPI-2358). We characterized the effects of KPU-300 on cell cycle kinetics and radiosensitization using HeLa cells expressing the fluorescent ubiquitination-based cell cycle indicator (Fucci). Cells treated with 30 nM...

Descripción completa

Detalles Bibliográficos
Autores principales: Okuyama, Kohei, Kaida, Atsushi, Hayashi, Yoshiki, Hayashi, Yoshio, Harada, Kiyoshi, Miura, Masahiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696839/
https://www.ncbi.nlm.nih.gov/pubmed/26716455
http://dx.doi.org/10.1371/journal.pone.0145995

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4696839/
https://www.ncbi.nlm.nih.gov/pubmed/26716455
http://dx.doi.org/10.1371/journal.pone.0145995

Ejemplares similares