Rapid Onset of Motor Deficits in a Mouse Model of Spinocerebellar Ataxia Type 6 Precedes Late Cerebellar Degeneration(1,2,3)

Spinocerebellar ataxia type 6 (SCA6) is an autosomal-dominant cerebellar ataxia that has been associated with loss of cerebellar Purkinje cells. Disease onset is typically at midlife, although it can vary widely from late teens to old age in SCA6 patients. Our study focused on an SCA6 knock-in mouse...

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Detalles Bibliográficos
Autores principales: Jayabal, Sriram, Ljungberg, Lovisa, Erwes, Thomas, Cormier, Alexander, Quilez, Sabrina, El Jaouhari, Sara, Watt, Alanna J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2015
Materias:
Confirmation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697081/
https://www.ncbi.nlm.nih.gov/pubmed/26730403
http://dx.doi.org/10.1523/ENEURO.0094-15.2015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697081/
https://www.ncbi.nlm.nih.gov/pubmed/26730403
http://dx.doi.org/10.1523/ENEURO.0094-15.2015

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