Non-equivalence of Key Positively Charged Residues of the Free Fatty Acid 2 Receptor in the Recognition and Function of Agonist Versus Antagonist Ligands

Short chain fatty acids (SCFAs) are produced in the gut by bacterial fermentation of poorly digested carbohydrates. A key mediator of their actions is the G protein-coupled free fatty acid 2 (FFA2) receptor, and this has been suggested as a therapeutic target for the treatment of both metabolic and...

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Detalles Bibliográficos
Autores principales: Sergeev, Eugenia, Hansen, Anders Højgaard, Pandey, Sunil K., MacKenzie, Amanda E., Hudson, Brian D., Ulven, Trond, Milligan, Graeme
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697166/
https://www.ncbi.nlm.nih.gov/pubmed/26518871
http://dx.doi.org/10.1074/jbc.M115.687939

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697166/
https://www.ncbi.nlm.nih.gov/pubmed/26518871
http://dx.doi.org/10.1074/jbc.M115.687939

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