Cargando…
Structure and Energetics of Allosteric Regulation of HCN2 Ion Channels by Cyclic Nucleotides
Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels play an important role in regulating electrical activity in the heart and brain. They are gated by the binding of cyclic nucleotides to a conserved, intracellular cyclic nucleotide-binding domain (CNBD), which is connected to the...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697172/ https://www.ncbi.nlm.nih.gov/pubmed/26559974 http://dx.doi.org/10.1074/jbc.M115.696450 |