Cargando…

Structure and Energetics of Allosteric Regulation of HCN2 Ion Channels by Cyclic Nucleotides

Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels play an important role in regulating electrical activity in the heart and brain. They are gated by the binding of cyclic nucleotides to a conserved, intracellular cyclic nucleotide-binding domain (CNBD), which is connected to the...

Descripción completa

Detalles Bibliográficos
Autores principales:	DeBerg, Hannah A., Brzovic, Peter S., Flynn, Galen E., Zagotta, William N., Stoll, Stefan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2016
Materias:	Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697172/ https://www.ncbi.nlm.nih.gov/pubmed/26559974 http://dx.doi.org/10.1074/jbc.M115.696450

Ejemplares similares

The HCN domain couples voltage gating and cAMP response in hyperpolarization-activated cyclic nucleotide-gated channels
por: Porro, Alessandro, et al.
Publicado: (2019)

A synthetic peptide that prevents cAMP regulation in mammalian hyperpolarization-activated cyclic nucleotide-gated (HCN) channels
por: Saponaro, Andrea, et al.
Publicado: (2018)

Mechanism of Allosteric Modulation of Rod Cyclic Nucleotide–gated Channels
por: Sunderman, Elizabeth R., et al.
Publicado: (1999)

Direct Regulation of Hyperpolarization-Activated Cyclic-Nucleotide Gated (HCN1) Channels by Cannabinoids
por: Mayar, Sultan, et al.
Publicado: (2022)

Sequence of Events Underlying the Allosteric Transition of Rod Cyclic Nucleotide–gated Channels
por: Sunderman, Elizabeth R., et al.
Publicado: (1999)

A Cysteine Scan of the Inner Vestibule of Cyclic Nucleotide–gated Channels Reveals Architecture and Rearrangement of the Pore
por: Flynn, Galen E., et al.
Publicado: (2003)

Ligand discrimination and gating in cyclic nucleotide-gated ion channels from apo and partial agonist-bound cryo-EM structures
por: Rheinberger, Jan, et al.
Publicado: (2018)

Helix breaking transition in the S4 of HCN channel is critical for hyperpolarization-dependent gating
por: Kasimova, Marina A, et al.
Publicado: (2019)

Interplay between VSD, pore, and membrane lipids in electromechanical coupling in HCN channels
por: Elbahnsi, Ahmad, et al.
Publicado: (2023)

Key features of an Hsp70 chaperone allosteric landscape revealed by ion-mobility native mass spectrometry and double electron-electron resonance
por: Lai, Alex L., et al.
Publicado: (2017)

Differential ion dehydration energetics explains selectivity in the non-canonical lysosomal K(+) channel TMEM175
por: Oh, SeCheol, et al.
Publicado: (2022)

Investigating cyclic nucleotide and cyclic dinucleotide binding to HCN channels by surface plasmon resonance
por: Hayoz, Sebastien, et al.
Publicado: (2017)

Ion Conductivity of the Bacterial Translocation Channel SecYEG Engaged in Translocation
por: Knyazev, Denis G., et al.
Publicado: (2014)

Single molecule FRET reveals pore size and opening mechanism of a mechano-sensitive ion channel
por: Wang, Yong, et al.
Publicado: (2014)

Conformational Flip of Nonactivated HCN2 Channel Subunits Evoked by Cyclic Nucleotides
por: Thon, Susanne, et al.
Publicado: (2015)

Novel Potassium Channels in Kidney Mitochondria: The Hyperpolarization-Activated and Cyclic Nucleotide-Gated HCN Channels
por: León-Aparicio, Daniel, et al.
Publicado: (2019)

Occupancy of the Zinc-binding Site by Transition Metals Decreases the Substrate Affinity of the Human Dopamine Transporter by an Allosteric Mechanism
por: Li, Yang, et al.
Publicado: (2017)

The Intracellular Amino Terminus Plays a Dominant Role in Desensitization of ATP-gated P2X Receptor Ion Channels
por: Allsopp, Rebecca C., et al.
Publicado: (2011)

Direct Gating of ATP-activated Ion Channels (P2X2 Receptors) by Lipophilic Attachment at the Outer End of the Second Transmembrane Domain
por: Rothwell, Simon W., et al.
Publicado: (2014)

Mechanism of Tetracaine Block of Cyclic Nucleotide-gated Channels
por: Fodor, Anthony A., et al.
Publicado: (1997)

Integrated Allosteric Model of Voltage Gating of Hcn Channels
por: Altomare, Claudia, et al.
Publicado: (2001)

Ligand-induced Epitope Masking: DISSOCIATION OF INTEGRIN α5β1-FIBRONECTIN COMPLEXES ONLY BY MONOCLONAL ANTIBODIES WITH AN ALLOSTERIC MODE OF ACTION
por: Mould, A. Paul, et al.
Publicado: (2016)

Molecular mechanism for 3:1 subunit stoichiometry of rod cyclic nucleotide-gated ion channels
por: Shuart, Noah G., et al.
Publicado: (2011)

Allosteric mechanism for KCNE1 modulation of KCNQ1 potassium channel activation
por: Kuenze, Georg, et al.
Publicado: (2020)

An external sodium ion binding site controls allosteric gating in TRPV1 channels
por: Jara-Oseguera, Andres, et al.
Publicado: (2016)

The molecular basis for an allosteric inhibition of K(+)-flux gating in K(2P) channels
por: Rinné, Susanne, et al.
Publicado: (2019)

Electromechanical coupling mechanism for activation and inactivation of an HCN channel
por: Dai, Gucan, et al.
Publicado: (2021)

Hyperpolarization-Activated Cyclic Nucleotide-Gated Non-selective (HCN) Ion Channels Regulate Human and Murine Urinary Bladder Contractility
por: Mader, Felix, et al.
Publicado: (2018)

Hyperpolarization-Activated Cyclic Nucleotide-Gated Ion (HCN) Channels Regulate PC12 Cell Differentiation Toward Sympathetic Neuron
por: Zhong, Li-Ying, et al.
Publicado: (2019)

Kcnh1 Voltage-gated Potassium Channels Are Essential for Early Zebrafish Development
por: Stengel, Rayk, et al.
Publicado: (2012)

Bibliometric analysis of hyperpolarization-activated cyclic nucleotide-gated (HCN)channels research (2004-2020)
por: Tian, Chuanxi, et al.
Publicado: (2022)

Allosteric regulators selectively prevent Ca(2+)-feedback of Ca(V) and Na(V) channels
por: Niu, Jacqueline, et al.
Publicado: (2018)

Recapitulation of an Ion Channel IV Curve Using Frequency Components
por: Rigby, John R., et al.
Publicado: (2011)

Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels
por: Rubaiy, Hussein N., et al.
Publicado: (2017)

Kir6.2-D323 and SUR2A-Q1336: an intersubunit interaction pairing for allosteric information transfer in the K(ATP) channel complex
por: Brennan, Sean, et al.
Publicado: (2020)

Effects of Ultraviolet Modification on the Gating Energetics of Cyclic Nucleotide–Gated Channels
por: Middendorf, Thomas R., et al.
Publicado: (2000)

Molecular mechanism of voltage-dependent potentiation of KCNH potassium channels
por: Dai, Gucan, et al.
Publicado: (2017)

Cation and voltage dependence of lidocaine inhibition of the hyperpolarization-activated cyclic nucleotide-gated HCN1 channel
por: Putrenko, Igor, et al.
Publicado: (2017)

Delineating an extracellular redox-sensitive module in T-type Ca(2+) channels
por: Huang, Dongyang, et al.
Publicado: (2020)

Tetracaine Reports a Conformational Change in the Pore of Cyclic Nucleotide–gated Channels
por: Fodor, Anthony A., et al.
Publicado: (1997)

Cannot write session to /tmp/vufind_sessions/sess_j5d9nnni496ruu80s3s980j29b