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Structure and Energetics of Allosteric Regulation of HCN2 Ion Channels by Cyclic Nucleotides

Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels play an important role in regulating electrical activity in the heart and brain. They are gated by the binding of cyclic nucleotides to a conserved, intracellular cyclic nucleotide-binding domain (CNBD), which is connected to the...

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Detalles Bibliográficos
Autores principales:	DeBerg, Hannah A., Brzovic, Peter S., Flynn, Galen E., Zagotta, William N., Stoll, Stefan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2016
Materias:	Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697172/ https://www.ncbi.nlm.nih.gov/pubmed/26559974 http://dx.doi.org/10.1074/jbc.M115.696450

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