Inhibition of Mitochondrial Complex II by the Anticancer Agent Lonidamine

The antitumor agent lonidamine (LND; 1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylic acid) is known to interfere with energy-yielding processes in cancer cells. However, the effect of LND on central energy metabolism has never been fully characterized. In this study, we report that a significant amo...

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Detalles Bibliográficos
Autores principales: Guo, Lili, Shestov, Alexander A., Worth, Andrew J., Nath, Kavindra, Nelson, David S., Leeper, Dennis B., Glickson, Jerry D., Blair, Ian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697178/
https://www.ncbi.nlm.nih.gov/pubmed/26521302
http://dx.doi.org/10.1074/jbc.M115.697516

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697178/
https://www.ncbi.nlm.nih.gov/pubmed/26521302
http://dx.doi.org/10.1074/jbc.M115.697516

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