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Inhibition of Mitochondrial Complex II by the Anticancer Agent Lonidamine

The antitumor agent lonidamine (LND; 1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylic acid) is known to interfere with energy-yielding processes in cancer cells. However, the effect of LND on central energy metabolism has never been fully characterized. In this study, we report that a significant amo...

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Detalles Bibliográficos
Autores principales:	Guo, Lili, Shestov, Alexander A., Worth, Andrew J., Nath, Kavindra, Nelson, David S., Leeper, Dennis B., Glickson, Jerry D., Blair, Ian A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2016
Materias:	Metabolism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697178/ https://www.ncbi.nlm.nih.gov/pubmed/26521302 http://dx.doi.org/10.1074/jbc.M115.697516

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