Overcoming Endocrine Resistance in Hormone-Receptor Positive Advanced Breast Cancer-The Emerging Role of CDK4/6 Inhibitors

Dysregulation of the cyclin D and cyclin-dependent kinase (CDK) pathway in cancer cells may inhibit senescence and promote cellular proliferation. By using various different mechanisms, malignant cells may increase cyclin D-dependent activity. The cyclin D-cyclin-dependent kinases 4 and 6 (CDK4/6)-r...

Descripción completa

Detalles Bibliográficos
Autor principal: O’Sullivan, Ciara C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697745/
https://www.ncbi.nlm.nih.gov/pubmed/26726315

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697745/
https://www.ncbi.nlm.nih.gov/pubmed/26726315

Ejemplares similares