Inflammatory PAF Receptor Signaling Initiates Hedgehog Signaling and Kidney Fibrogenesis During Ethanol Consumption

Acute inflammation either resolves or proceeds to fibrotic repair that replaces functional tissue. Pro-fibrotic hedgehog signaling and induction of its Gli transcription factor in pericytes induces fibrosis in kidney, but molecular instructions connecting inflammation to fibrosis are opaque. We show...

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Detalles Bibliográficos
Autores principales: Latchoumycandane, Calivarathan, Hanouneh, Mohamad, Nagy, Laura E., McIntyre, Thomas M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697844/
https://www.ncbi.nlm.nih.gov/pubmed/26720402
http://dx.doi.org/10.1371/journal.pone.0145691

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697844/
https://www.ncbi.nlm.nih.gov/pubmed/26720402
http://dx.doi.org/10.1371/journal.pone.0145691

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