Cargando…
Conformational Fine-Tuning of Pore-Forming Peptide Potency and Selectivity
[Image: see text] To better understand the sequence–structure–function relationships that control the activity and selectivity of membrane-permeabilizing peptides, we screened a peptide library, based on the archetypal pore-former melittin, for loss-of-function variants. This was accomplished by ass...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2015
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697923/ https://www.ncbi.nlm.nih.gov/pubmed/26632653 http://dx.doi.org/10.1021/jacs.5b10595 |