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Conformational Fine-Tuning of Pore-Forming Peptide Potency and Selectivity

[Image: see text] To better understand the sequence–structure–function relationships that control the activity and selectivity of membrane-permeabilizing peptides, we screened a peptide library, based on the archetypal pore-former melittin, for loss-of-function variants. This was accomplished by ass...

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Detalles Bibliográficos
Autores principales:	Krauson, Aram J., Hall, O. Morgan, Fuselier, Taylor, Starr, Charles G., Kauffman, W. Berkeley, Wimley, William C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2015
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4697923/ https://www.ncbi.nlm.nih.gov/pubmed/26632653 http://dx.doi.org/10.1021/jacs.5b10595

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