Structure-Activity Relationship and in Vivo Anti-Tumor Evaluations of Dictyoceratin-A and -C, Hypoxia-Selective Growth Inhibitors from Marine Sponge

Oral dictyoceratin-C (1) and A (2), hypoxia-selective growth inhibitors, showed potent in vivo antitumor effects in mice subcutaneously inoculated with sarcoma S180 cells. Structurally modified analogs were synthesized to assess the structure–activity relationship of the natural compounds 1 and 2 is...

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Detalles Bibliográficos
Autores principales: Sumii, Yuji, Kotoku, Naoyuki, Fukuda, Akinori, Kawachi, Takashi, Arai, Masayoshi, Kobayashi, Motomasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699247/
https://www.ncbi.nlm.nih.gov/pubmed/26694423
http://dx.doi.org/10.3390/md13127074

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699247/
https://www.ncbi.nlm.nih.gov/pubmed/26694423
http://dx.doi.org/10.3390/md13127074

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