Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling

BACKGROUND: Chronic psychological stress is associated with accelerated aging and increased risk for aging-related diseases, but the underlying molecular mechanisms are unclear. RESULTS: We examined the effect of lifetime stressors on a DNA methylation-based age predictor, epigenetic clock. After co...

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Detalles Bibliográficos
Autores principales: Zannas, Anthony S., Arloth, Janine, Carrillo-Roa, Tania, Iurato, Stella, Röh, Simone, Ressler, Kerry J., Nemeroff, Charles B., Smith, Alicia K., Bradley, Bekh, Heim, Christine, Menke, Andreas, Lange, Jennifer F., Brückl, Tanja, Ising, Marcus, Wray, Naomi R., Erhardt, Angelika, Binder, Elisabeth B., Mehta, Divya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699359/
https://www.ncbi.nlm.nih.gov/pubmed/26673150
http://dx.doi.org/10.1186/s13059-015-0828-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699359/
https://www.ncbi.nlm.nih.gov/pubmed/26673150
http://dx.doi.org/10.1186/s13059-015-0828-5

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