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Rev1 promotes replication through UV lesions in conjunction with DNA polymerases η, ι, and κ but not DNA polymerase ζ

Translesion synthesis (TLS) DNA polymerases (Pols) promote replication through DNA lesions; however, little is known about the protein factors that affect their function in human cells. In yeast, Rev1 plays a noncatalytic role as an indispensable component of Polζ, and Polζ together with Rev1 mediat...

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Detalles Bibliográficos
Autores principales: Yoon, Jung-Hoon, Park, Jeseong, Conde, Juan, Wakamiya, Maki, Prakash, Louise, Prakash, Satya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699387/
https://www.ncbi.nlm.nih.gov/pubmed/26680302
http://dx.doi.org/10.1101/gad.272229.115