Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation

Stromal fibroblast senescence has been linked to aging-associated cancer risk. However, density and proliferation of cancer-associated fibroblasts (CAF) are frequently increased. Loss or down-modulation of the Notch effector CSL/RBP-Jκ in dermal fibroblasts is sufficient for CAF activation and ensui...

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Detalles Bibliográficos
Autores principales: Procopio, Maria-Giuseppina, Laszlo, Csaba, Labban, Dania Al, Kim, Dong Eun, Bordignon, Pino, Jo, Seunghee, Goruppi, Sandro, Menietti, Elena, Ostano, Paola, Ala, Ugo, Provero, Paolo, Hoetzenecker, Wolfram, Neel, Victor, Kilarski, Witek, Swartz, Melody A., Brisken, Cathrin, Lefort, Karine, Dotto, G. Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699446/
https://www.ncbi.nlm.nih.gov/pubmed/26302407
http://dx.doi.org/10.1038/ncb3228

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699446/
https://www.ncbi.nlm.nih.gov/pubmed/26302407
http://dx.doi.org/10.1038/ncb3228

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