A First-Time-In-Human Phase I Clinical Trial of Bispecific Antibody-Targeted, Paclitaxel-Packaged Bacterial Minicells

BACKGROUND: We have harnessed a novel biological system, the bacterial minicell, to deliver cancer therapeutics to cancer cells. Preclinical studies showed that epidermal growth factor receptor (EGFR)-targeted, paclitaxel-loaded minicells ((EGFR)minicells(Pac)) have antitumor effects in xenograft mo...

Descripción completa

Detalles Bibliográficos
Autores principales: Solomon, Benjamin J., Desai, Jayesh, Rosenthal, Mark, McArthur, Grant A., Pattison, Scott T., Pattison, Stacey L., MacDiarmid, Jennifer, Brahmbhatt, Himanshu, Scott, Andrew M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699457/
https://www.ncbi.nlm.nih.gov/pubmed/26659127
http://dx.doi.org/10.1371/journal.pone.0144559

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699457/
https://www.ncbi.nlm.nih.gov/pubmed/26659127
http://dx.doi.org/10.1371/journal.pone.0144559

Ejemplares similares