Mutations to Less-Preferred Synonymous Codons in a Highly Expressed Gene of Escherichia coli: Fitness and Epistatic Interactions

Codon-tRNA coevolution to maximize protein production has been, until recently, the dominant hypothesis to explain codon-usage bias in highly expressed bacterial genes. Two predictions of this hypothesis are 1) selection is weak; and 2) similar silent replacements at different codons should have sim...

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Detalles Bibliográficos
Autores principales: Hauber, David J., Grogan, Dennis W., DeBry, Ronald W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699635/
https://www.ncbi.nlm.nih.gov/pubmed/26727272
http://dx.doi.org/10.1371/journal.pone.0146375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699635/
https://www.ncbi.nlm.nih.gov/pubmed/26727272
http://dx.doi.org/10.1371/journal.pone.0146375

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