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Nitric Oxide-cGMP Signaling Stimulates Erythropoiesis through Multiple Lineage-Specific Transcription Factors: Clinical Implications and a Novel Target for Erythropoiesis
Much attention has been directed to the physiological effects of nitric oxide (NO)-cGMP signaling, but virtually nothing is known about its hematologic effects. We reported for the first time that cGMP signaling induces human γ-globin gene expression. Aiming at developing novel therapeutics for anem...
Autores principales: | Ikuta, Tohru, Sellak, Hassan, Odo, Nadine, Adekile, Adekunle D., Gaensler, Karin M. L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699757/ https://www.ncbi.nlm.nih.gov/pubmed/26727002 http://dx.doi.org/10.1371/journal.pone.0144561 |
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