Coordinating Role of RXRα in Downregulating Hepatic Detoxification during Inflammation Revealed by Fuzzy-Logic Modeling

During various inflammatory processes circulating cytokines including IL-6, IL-1β, and TNFα elicit a broad and clinically relevant impairment of hepatic detoxification that is based on the simultaneous downregulation of many drug metabolizing enzymes and transporter genes. To address the question wh...

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Detalles Bibliográficos
Autores principales: Keller, Roland, Klein, Marcus, Thomas, Maria, Dräger, Andreas, Metzger, Ute, Templin, Markus F., Joos, Thomas O., Thasler, Wolfgang E., Zell, Andreas, Zanger, Ulrich M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699813/
https://www.ncbi.nlm.nih.gov/pubmed/26727233
http://dx.doi.org/10.1371/journal.pcbi.1004431

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699813/
https://www.ncbi.nlm.nih.gov/pubmed/26727233
http://dx.doi.org/10.1371/journal.pcbi.1004431

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