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Access Path to the Ligand Binding Pocket May Play a Role in Xenobiotics Selection by AhR
Understanding of multidrug binding at the atomic level would facilitate drug design and strategies to modulate drug metabolism, including drug transport, oxidation, and conjugation. Therefore we explored the mechanism of promiscuous binding of small molecules by studying the ligand binding domain, t...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699818/ https://www.ncbi.nlm.nih.gov/pubmed/26727491 http://dx.doi.org/10.1371/journal.pone.0146066 |