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Bacterial Proliferation: Keep Dividing and Don't Mind the Gap

DNA Damage Tolerance (DDT) mechanisms help dealing with unrepaired DNA lesions that block replication and challenge genome integrity. Previous in vitro studies showed that the bacterial replicase is able to re-prime downstream of a DNA lesion, leaving behind a single-stranded DNA gap. The question r...

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Detalles Bibliográficos
Autores principales: Laureti, Luisa, Demol, Julien, Fuchs, Robert P., Pagès, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699847/
https://www.ncbi.nlm.nih.gov/pubmed/26713761
http://dx.doi.org/10.1371/journal.pgen.1005757