In vitro and in vivo downregulation of the ATP binding cassette transporter B1 by the HMG-CoA reductase inhibitor simvastatin

Extrusion of chemotherapeutics by ATP-binding cassette (ABC) transporters like ABCB1 (P-glycoprotein) represents a crucial mechanism of multidrug resistance in cancer therapy. We have previously shown that the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor simvastatin directly i...

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Detalles Bibliográficos
Autores principales: Atil, Bihter, Berger-Sieczkowski, Evelyn, Bardy, Johanna, Werner, Martin, Hohenegger, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700083/
https://www.ncbi.nlm.nih.gov/pubmed/26319048
http://dx.doi.org/10.1007/s00210-015-1169-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700083/
https://www.ncbi.nlm.nih.gov/pubmed/26319048
http://dx.doi.org/10.1007/s00210-015-1169-3

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