Receptor Crosslinking: A General Method to Trigger Internalization and Lysosomal Targeting of Therapeutic Receptor:Ligand Complexes

A major unmet clinical need is a universal method for subcellular targeting of bioactive molecules to lysosomes. Delivery to this organelle enables either degradation of oncogenic receptors that are overexpressed in cancers, or release of prodrugs from antibody–drug conjugates. Here, we describe a g...

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Detalles Bibliográficos
Autores principales: Moody, Paul R, Sayers, Edward J, Magnusson, Johannes P, Alexander, Cameron, Borri, Paola, Watson, Peter, Jones, Arwyn T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700114/
https://www.ncbi.nlm.nih.gov/pubmed/26412588
http://dx.doi.org/10.1038/mt.2015.178

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700114/
https://www.ncbi.nlm.nih.gov/pubmed/26412588
http://dx.doi.org/10.1038/mt.2015.178

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