Antimalarial activity of artefenomel (OZ439), a novel synthetic antimalarial endoperoxide, in patients with Plasmodium falciparum and Plasmodium vivax malaria: an open-label phase 2 trial

BACKGROUND: Artefenomel (OZ439) is a novel synthetic trioxolane with improved pharmacokinetic properties compared with other antimalarial drugs with the artemisinin pharmacophore. Artefenomel has been generally well tolerated in volunteers at doses up to 1600 mg and is being developed as a partner d...

Descripción completa

Detalles Bibliográficos
Autores principales: Phyo, Aung Pyae, Jittamala, Podjanee, Nosten, François H, Pukrittayakamee, Sasithon, Imwong, Mallika, White, Nicholas J, Duparc, Stephan, Macintyre, Fiona, Baker, Mark, Möhrle, Jörg J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science ;, The Lancet Pub. Group 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700386/
https://www.ncbi.nlm.nih.gov/pubmed/26448141
http://dx.doi.org/10.1016/S1473-3099(15)00320-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700386/
https://www.ncbi.nlm.nih.gov/pubmed/26448141
http://dx.doi.org/10.1016/S1473-3099(15)00320-5

Ejemplares similares