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TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress

Cellular genomes are highly vulnerable to perturbations to chromosomal DNA replication. Proliferating cell nuclear antigen (PCNA), the processivity factor for DNA replication, plays a central role as a platform for recruitment of genome surveillance and DNA repair factors to replication forks, allow...

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Detalles Bibliográficos
Autores principales: Hoffmann, Saskia, Smedegaard, Stine, Nakamura, Kyosuke, Mortuza, Gulnahar B., Räschle, Markus, Ibañez de Opakua, Alain, Oka, Yasuyoshi, Feng, Yunpeng, Blanco, Francisco J., Mann, Matthias, Montoya, Guillermo, Groth, Anja, Bekker-Jensen, Simon, Mailand, Niels
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700480/
https://www.ncbi.nlm.nih.gov/pubmed/26711499
http://dx.doi.org/10.1083/jcb.201506071