Cargando…
TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress
Cellular genomes are highly vulnerable to perturbations to chromosomal DNA replication. Proliferating cell nuclear antigen (PCNA), the processivity factor for DNA replication, plays a central role as a platform for recruitment of genome surveillance and DNA repair factors to replication forks, allow...
Autores principales: | Hoffmann, Saskia, Smedegaard, Stine, Nakamura, Kyosuke, Mortuza, Gulnahar B., Räschle, Markus, Ibañez de Opakua, Alain, Oka, Yasuyoshi, Feng, Yunpeng, Blanco, Francisco J., Mann, Matthias, Montoya, Guillermo, Groth, Anja, Bekker-Jensen, Simon, Mailand, Niels |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700480/ https://www.ncbi.nlm.nih.gov/pubmed/26711499 http://dx.doi.org/10.1083/jcb.201506071 |
Ejemplares similares
-
Mitotic replisome disassembly depends on TRAIP ubiquitin ligase activity
por: Priego Moreno, Sara, et al.
Publicado: (2019) -
TRAIP regulates replication fork recovery and progression via PCNA
por: Feng, Wanjuan, et al.
Publicado: (2016) -
TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication
por: Sonneville, Remi, et al.
Publicado: (2019) -
Defects in DNA Ligase I Trigger PCNA Ubiquitination at Lysine 107
por: Das-Bradoo, Sapna, et al.
Publicado: (2009) -
The ubiquitin ligase RFWD3 is required for translesion DNA synthesis
por: Gallina, Irene, et al.
Publicado: (2021)