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Restriction of protein synthesis abolishes senescence features at cellular and organismal levels

Cellular senescence or its equivalence is induced by treatment of cells with an appropriate inducer of senescence in various cell types. Mild restriction of cytoplasmic protein synthesis prevented induction of all aspects of cellular senescence in normal and tumor-derived human cells. It allowed the...

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Detalles Bibliográficos
Autores principales: Takauji, Yuki, Wada, Takumi, Takeda, Asuka, Kudo, Ikuru, Miki, Kensuke, Fujii, Michihiko, Ayusawa, Dai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700526/
https://www.ncbi.nlm.nih.gov/pubmed/26729469
http://dx.doi.org/10.1038/srep18722