HIV-1 latency and virus production from unintegrated genomes following direct infection of resting CD4 T cells

BACKGROUND: HIV-1 integration is prone to a high rate of failure, resulting in the accumulation of unintegrated viral genomes (uDNA) in vivo and in vitro. uDNA can be transcriptionally active, and circularized uDNA genomes are biochemically stable in non-proliferating cells. Resting, non-proliferati...

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Detalles Bibliográficos
Autores principales: Chan, Chi N., Trinité, Benjamin, Lee, Caroline S., Mahajan, Saurabh, Anand, Akanksha, Wodarz, Dominik, Sabbaj, Steffanie, Bansal, Anju, Goepfert, Paul A., Levy, David N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700562/
https://www.ncbi.nlm.nih.gov/pubmed/26728316
http://dx.doi.org/10.1186/s12977-015-0234-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700562/
https://www.ncbi.nlm.nih.gov/pubmed/26728316
http://dx.doi.org/10.1186/s12977-015-0234-9

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