Improved transcription and translation with L-leucine stimulation of mTORC1 in Roberts syndrome

BACKGROUND: Roberts syndrome (RBS) is a human developmental disorder caused by mutations in the cohesin acetyltransferase ESCO2. We previously reported that mTORC1 signaling was depressed and overall translation was reduced in RBS cells and zebrafish models for RBS. Treatment of RBS cells and zebraf...

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Detalles Bibliográficos
Autores principales: Xu, Baoshan, Gogol, Madelaine, Gaudenz, Karin, Gerton, Jennifer L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700579/
https://www.ncbi.nlm.nih.gov/pubmed/26729373
http://dx.doi.org/10.1186/s12864-015-2354-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700579/
https://www.ncbi.nlm.nih.gov/pubmed/26729373
http://dx.doi.org/10.1186/s12864-015-2354-y

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