Single point mutation in adeno-associated viral vectors -DJ capsid leads to improvement for gene delivery in vivo

BACKGROUND: Rational design of AAV capsids is a simple method for enhancing AAV transduction efficiency. AAV-DJ is a highly recombinogenic hybrid vector created from DNA shuffling of eight AAV serotypes, which mediates efficient gene expression both in vitro and in vivo. AAV2 and AAV8 are the closes...

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Detalles Bibliográficos
Autores principales: Mao, Yingying, Wang, Xuejun, Yan, Renhe, Hu, Wei, Li, Andrew, Wang, Shengqi, Li, Hongwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700607/
https://www.ncbi.nlm.nih.gov/pubmed/26729248
http://dx.doi.org/10.1186/s12896-015-0230-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700607/
https://www.ncbi.nlm.nih.gov/pubmed/26729248
http://dx.doi.org/10.1186/s12896-015-0230-0

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